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Life Extension Optimized Quercetin
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.8
Supplement Facts
Serving Size:  1 Vegetarian Capsule
Amount Per Serving
%DV
Vitamin C (from ascorbic acid, camu-camu berry extract)
30 mg
33%
Quercetin (as quercetin dihydrate)
250 mg
**
Optimized Food Blend[onion (bulb) (extracts), bitter orange bioflavonoids (peel and fruit), apple (fruit)
220 mg
**
Camu-camu extract (wildcrafted berry)
50 mg
**

Top Medical Research Studies

8
Quercetin shows potential for heart protection
Impact of quercetin in patients with myocardial infarction. A multicenter, randomized, and open-label pilot study.
Promising but needs further validation.
We investigated the addition of quercetin to standard treatment in patients experiencing their first heart attack. In this multicenter study with 143 participants, quercetin was administered during the critical early hours of treatment.

The results showed a significant reduction in heart tissue damage compared to those who only received standard therapy. Specifically, fewer patients in the quercetin group experienced internal bleeding in the heart muscle.

While the initial findings are promising, additional studies are needed to confirm these benefits.
Read More
8
Isoquercetin shows heart protection
Isoquercetin ameliorates myocardial infarction through anti-inflammation and anti-apoptosis factor and regulating TLR4-NF-κB signal pathway.
Promising but requires human trials
We investigated how isoquercetin interacts with heart attack, using a rat model to uncover its protective effects. Our findings showed that isoquercetin reduced heart damage, inflammation, and cell death associated with myocardial infarction. It also improved certain enzyme levels and suppressed a key signaling pathway linked to heart stress. While promising, these results suggest isoquercetin may be beneficial for heart health, though further research in humans is needed to confirm its effectiveness.
Read More
9
Quercetin enhances heart recovery post-MI
Preventive Administration of Quercetin Promotes Survival and Reduces Adverse Ventricular Remodeling after myocardial infarction through facilitating M2-like macrophage polarization.
High relevance for heart health
We explored how quercetin, a common bioflavonoid found in fruits and vegetables, might impact recovery after a heart attack. In our study with mice, treating them with quercetin before inducing a heart attack led to better heart function and increased survival rates.

We noticed that quercetin helped reduce heart swelling and injury size, while also lowering inflammation. Notably, it encouraged a shift in immune cells to a more healing state. Overall, while quercetin shows promise, further research is needed to fully understand its potential in heart attack prevention and treatment.
Read More

Most Useful Reviews

9.5
Promotes heart longevity
Quercetin supports heart health and longevity.
Read More
8.8
Improves general health
I opted for this quercetin for its numerous health advantages including antioxidant effects and support for heart and vascular health. Life Extension’s formula, enriched with rutin, enhances bioavailability. As a vegetarian, I appreciate that the capsules are easy to swallow. Since starting on Optimized Quercetin, I’ve noticed reduced inflammation, remarkable heart health improvement, and overall increased energy levels.
Read More
0
No noticeable effect
After taking quercetin for two months on my cardiologist’s advice, I noticed no changes in my body whatsoever. My heart didn’t feel better, nor did my energy levels increase. There were no negative effects either.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.3
  • All Researches
9
Quercetin enhances heart recovery post-MI
Preventive Administration of Quercetin Promotes Survival and Reduces Adverse Ventricular Remodeling after myocardial infarction through facilitating M2-like macrophage polarization.
High relevance for heart health
We explored how quercetin, a common bioflavonoid found in fruits and vegetables, might impact recovery after a heart attack. In our study with mice, treating them with quercetin before inducing a heart attack led to better heart function and increased survival rates.

We noticed that quercetin helped reduce heart swelling and injury size, while also lowering inflammation. Notably, it encouraged a shift in immune cells to a more healing state. Overall, while quercetin shows promise, further research is needed to fully understand its potential in heart attack prevention and treatment.
Read More
9
Quercetin promotes heart tissue protection
CircPAN3/miR-221/PTEN axis and apoptosis in myocardial Infarction: Quercetin's regulatory effects.
Significant relevance in cardioprotection
We investigated how quercetin influences recovery after a heart attack. By inducing heart attacks in rats and treating them with quercetin, we found that it actively reduced harmful protein levels associated with heart damage.

Specifically, quercetin decreased the expression of circPAN3 and PTEN while boosting miR-221, which are important for cell survival. These changes suggest that quercetin may help protect heart tissue after a myocardial infarction, improving heart function.
Read More
9
Senolytics enhance heart recovery
Pharmacological clearance of senescent cells improves cardiac remodeling and function after myocardial infarction in female aged mice.
Highly relevant to cardiac health
We investigated how quercetin, combined with another drug, affects heart recovery after a heart attack in older female mice.

This study showed that using senolytics, specifically dasatinib and quercetin, helped improve heart function and repair by clearing out toxic, aged cells in the heart.

By eliminating these harmful cells, we enhanced heart performance and regeneration.

Overall, our findings suggest that targeting senescent cells could be a promising approach for improving heart health in aging females after a heart attack.
Read More
9
Hyperoside shows heart protection
The role and mechanism of hyperoside against myocardial infarction in mice by regulating autophagy via NLRP1 inflammation pathway.
Relevant findings on heart health.
We explored the effects of hyperoside (Hyp), a compound from traditional Chinese medicine, on heart attacks in mice. In our study, we created a heart attack model and treated the mice with varying doses of Hyp for two weeks.

We observed significant improvements in heart function and reduced heart damage in the Hyp-treated groups compared to those without treatment. Hyp works partly by enhancing autophagy, which helps control inflammation related to heart injury.

Overall, our findings suggest that hyperoside may offer protective benefits for heart health.
Read More
9
Quercetin shows protective effects
Quercetin protects against experimentally-induced myocardial infarction in rats by an antioxidant potential and concomitant activation of signal transducer and activator of transcription 3.
Moderate relevance to heart health
We explored whether quercetin can protect against heart attacks in rats through its influence on specific cellular pathways. The study involved different groups of rats, some receiving quercetin before inducing heart attacks. The results showed that quercetin reduced heart damage, improved heart function, and decreased harmful substances in the body.

However, it’s important to note that while quercetin had protective effects, its full impact on heart attack treatment remains unclear. Overall, quercetin appears beneficial by enhancing antioxidant defenses and influencing relevant signaling pathways.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 5 Reviews
7.8
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9.5
Promotes heart longevity
Quercetin supports heart health and longevity.
8.8
Improves general health
I opted for this quercetin for its numerous health advantages including antioxidant effects and support for heart and vascular health. Life Extension’s formula, enriched with rutin, enhances bioavailability. As a vegetarian, I appreciate that the capsules are easy to swallow. Since starting on Optimized Quercetin, I’ve noticed reduced inflammation, remarkable heart health improvement, and overall increased energy levels.
Read More
0
No noticeable effect
After taking quercetin for two months on my cardiologist’s advice, I noticed no changes in my body whatsoever. My heart didn’t feel better, nor did my energy levels increase. There were no negative effects either.
7.5
Boosts immunity
Life Extension Quercetin capsules genuinely enhance my immunity and overall well-being! As someone who values natural health, these capsules have exceeded my expectations. Quercetin is a robust antioxidant that promotes heart health, boosts immunity, and lowers inflammation. After regular use, I've experienced reduced allergy symptoms, increased energy, and stronger immunity. The packaging is user-friendly and practical.
Read More
8.8
Essential heart supplement
Great supplement. I will order more as its quality is excellent. It is irreplaceable for the heart.
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